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This document details the first total synthesis of the indolizidinium alkaloid ficuseptine, utilizing a five-step process that includes palladium-catalyzed cross-coupling reactions. Key methods include a novel Sandmeyer-type iodination and the successful introduction of a C3 building block into the pyridine ring. The synthesized ficuseptine demonstrated potent antifungal activity, with ongoing research to evaluate its mechanism of action.

Author

Tazkiyatan Isria

Language

EN