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Novel NO Biosensor Based on the Surface Derivatization of GaAs by “Hinged” Iron porphyrins by Deng Guo Wu; Gonen Ashkenasy; Dmitry Shvarts; Rachel V. Ussyshkin; Ron Naaman; Abraham Shanzer; David Cahen is a Chemistry article available to read on EtoBox.
What is Novel NO Biosensor Based on the Surface Derivatization of GaAs by “Hinged” Iron porphyrins about?
Nitric oxide (NO) plays an important role in biology as a mediator, for example, of the endothelial-derived relaxing factor (EDRF)Ðan agent responsible for the regulation of blood vessel relaxation and for the maintenance of blood pressure. [1] Concentrations of 30 to 300 ppm of NO (1 ppm % 3.3 Â 10 À5 m) are sufficient to activate the guanylyl cyclase signaling cascade. [2] Since NO is a gaseous and highly reactive species, its direct detection at low concentrations is difficult. The methods used to sense NO have generally been based on following changes in the UV/Vis spectra or electrochemical properties of the sensing elements. [3] Electron paramagnetic resonance (EPR) and NMR image visualization of the distributions of NO free radicals in vivo were also reported, but were found to be limited by spatial resolution and sample size. [4, 5] We report here a novel approach for the direct detection of low concentrations of NO free radicals in physiological aqueous solution (pH 7.4). The Molecular Controlled Semiconductor Resistor (MOCSER; see reference [6]) provides an excellent way to The use of this spin-trap for the in vivo detection of NO is more problematic because of the presen
Who reads Novel NO Biosensor Based on the Surface Derivatization of GaAs by “Hinged” Iron porphyrins?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Deng Guo Wu; Gonen Ashkenasy; Dmitry Shvarts; Rachel V. Ussyshkin; Ron Naaman; Abraham Shanzer; David Cahen
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley; Research Square (ISSN 0044-8249)
- Published
- 2000
- Language
- EN
- Field
- Chemistry (Physical Sciences)