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Endothelial Endothelin Receptor A Expression Is Associated With Podocyte Injury and Oxidative Stress in Patients With Focal Segmental Glomerulosclerosis by van de Lest, Nina A. (author);Bakker, Aimée E. (author);Dijkstra, Kyra L. (author);Zandbergen, Malu (author);Heemskerk, Sharon A.C. (author);Wolterbeek, Ron (author);Bruijn, Jan A. (author);Scharpfenecker, Marion (author) is a Medicine article available to read on EtoBox.

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## Introduction: The podocyte is thought to be the mainly affected cell type in focal segmental glomerulosclerosis (fsgs). however, recent studies have also indicated a role for glomerular endothelial cells and podocyte-endothelial crosstalk in fsgs development. an experimental model for podocyte injury showed that increased endothelin-1 (et-1) signaling between podocytes and endothelial cells induces endothelial oxidative stress and subsequent podocyte loss. in the current study, we investigated endothelial endothelin receptor a (etr) expression in patients with fsgs and its association with podocyte injury and glomerular oxidative stress. ## Methods: We selected 39 biopsy samples of patients with fsgs and 8 healthy control subjects, and stained them for etr, nephrin and 8-oxo-guanine, a dna lesion caused by oxidative damage. glomeruli with etr-positive endothelium and with nephrin loss were scored, and the 8-oxo-guanine-positive glomerular area was measured. ## Results: The mean percentage of glomeruli with etr-positive endothelial cells in patients with fsgs was higher compared to that in healthy control subjects (52% vs. 7%; < 0.001). the presence of glomerular etr-positive en

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Author

van de Lest, Nina A. (author);Bakker, Aimée E. (author);Dijkstra, Kyra L. (author);Zandbergen, Malu (author);Heemskerk, Sharon A.C. (author);Wolterbeek, Ron (author);Bruijn, Jan A. (author);Scharpfenecker, Marion (author)

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)