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Diagnostic and Dosimetry Features of [64Cu]CuCl2 in High-Grade Paediatric Infiltrative Gliomas by Francesco Fiz; Gianluca Bottoni; Martina Ugolini; Sergio Righi; Alessio Cirone; Maria Carmen Garganese; Antonio Verrico; Andrea Rossi; Claudia Milanaccio; Antonia Ramaglia; Angela Mastronuzzi; Massimo Eraldo Abate; Antonella Cacchione; Carlo Gandolfo; Giovanna Stefania Colafati; Maria Luisa Garrè; Giovanni Morana; Arnoldo Piccardo is a Medicine article available to read on EtoBox.
What is Diagnostic and Dosimetry Features of [64Cu]CuCl2 in High-Grade Paediatric Infiltrative Gliomas about?
Purpose of the Report Paediatric diffuse high-grade gliomas (PDHGG) are rare central nervous system neoplasms lacking effective therapeutic options. Molecular imaging of tumour metabolism might identify novel diagnostic/therapeutic targets. In this study, we evaluated the distribution and the dosimetry aspects of [ 64 Cu]CuCl 2 in PDHGG subjects, as copper is a key element in cellular metabolism whose turnover may be increased in tumour cells. Material and Methods Paediatric patients with PDHGG were prospectively recruited. [ 64 Cu]CuCl 2 PET/CT was performed 1 h after tracer injection; if the scan was positive, it was repeated 24 and 72 h later. Lesion standardised uptake value (SUV) and target-to-background ratio (TBR) were calculated. Tumour and organ dosimetry were computed using the MIRD algorithm. Each patient underwent an MRI scan, including FLAIR, T2-weighted and post-contrast T1-weighted imaging. Results Ten patients were enrolled (median age 9, range 6-16 years, 6 females). Diagnoses were diffuse midline gliomas (n = 8, 5 of which with H3K27 alterations) and diffuse hemispheric gliomas (n = 2). Six patients had visible tracer uptake (SUV: 1.0 ± 0.6 TBR: 5 ± 3.1). [ 64 Cu]
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- Author
- Francesco Fiz; Gianluca Bottoni; Martina Ugolini; Sergio Righi; Alessio Cirone; Maria Carmen Garganese; Antonio Verrico; Andrea Rossi; Claudia Milanaccio; Antonia Ramaglia; Angela Mastronuzzi; Massimo Eraldo Abate; Antonella Cacchione; Carlo Gandolfo; Giovanna Stefania Colafati; Maria Luisa Garrè; Giovanni Morana; Arnoldo Piccardo
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)