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What is Article p105 about?

This study evaluates the pharmacokinetics of injectable dexamethasone sodium phosphate (DSPI) administered orally compared to dexamethasone oral concentrate (DOC) in healthy adults. The results indicate that DSPI is not bioequivalent to DOC when taken orally, with a relative bioavailability of 87.4% for AUC(0-t) and 91.1% for AUC(0-∞). Despite the differences in pharmacokinetic parameters, the efficacy of DSPI supports its use in emergency departments for treating conditions like pediatric asthma and croup.

Author

Herminia Castillo Valencia

Language

EN