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Associations of Angiotensinogen Gene Mutations with Hypertension and Myocardial Infarction in a Gulf Population by Philippe M Frossard; Susan H Hill; Yassin I Elshahat; Eniyoma N Obineche; Awais M Bokhari; Gilles G Lestringant; Anne John; Abdishakur M Abdulle is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Associations of Angiotensinogen Gene Mutations with Hypertension and Myocardial Infarction in a Gulf Population about?
To date, the human angiotensinogen (__AGT__) gene and some of its variants represent the best examples of genetic influences that are involved in the determination of essential hypertension (EH) and associated cardiovascular diseases (CVDs). To assess the value of genotyping __AGT__ in a genetically homogeneous population, we carried out a retrospective, case–control study of variants M235T and T174M for putative correlations with CVDs among nationals from the United Arab Emirates (Emirati) – an ethnic group characterized by no alcohol intake and no cigarette smoking. We investigated a sample population of 229 Emirati (119 males and 110 females), comprising groups of controls and patients with clinical diagnoses of EH, left ventricular hypertrophy (LVH), ischaemic heart disease (IHD) and myocardial infarction (MI). M235T and T174M alleles were determined via assays based on the polymerase chain reaction. T174M showed no correlation with any of the four clinical entities included in this study. T235 alleles, however, occurred more frequently in the EH group and less frequently in the group of MI survivors. We also found that T235 allele frequencies decreased with age, indicating tha
Who reads Associations of Angiotensinogen Gene Mutations with Hypertension and Myocardial Infarction in a Gulf Population?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Philippe M Frossard; Susan H Hill; Yassin I Elshahat; Eniyoma N Obineche; Awais M Bokhari; Gilles G Lestringant; Anne John; Abdishakur M Abdulle
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0009-9163)
- Published
- 1998
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)