Opening book details…
Can I read Particle Formation by Rapid Expansion from Solution Using Near-critical Dimethyl-ether on EtoBox?
Particle Formation by Rapid Expansion from Solution Using Near-critical Dimethyl-ether by Marilyn Calderone; Stephen Tallon is a Engineering article available to read on EtoBox.
What is Particle Formation by Rapid Expansion from Solution Using Near-critical Dimethyl-ether about?
The present experimental work examines the use of dimethyl-ether (DME) in a process for formation of particulate materials. DME is used in the sub-critical liquid state as a solvent which partially vaporizes as it is sprayed through a nozzle and then evaporates to leave a fine, dry, solvent free powder. DME is an effective solvent for a range of polar compounds, including many pharmaceutical compounds, and good product throughput rates can be achieved. The spray characteristics are investigated here in terms of the hydrodynamics and thermodynamics of the depressurization step, and using a visual analysis of the profile of the spray. The process is demonstrated using acetaminophen as a model solute, and the resulting particles are characterized by SEM analysis and measurement of their dissolution rate in water. Measurements of the solubility of acetaminophen in DME are also reported.
Who reads Particle Formation by Rapid Expansion from Solution Using Near-critical Dimethyl-ether?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Marilyn Calderone; Stephen Tallon
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0896-8446)
- Published
- 2008
- Language
- EN
- Field
- Engineering (Physical Sciences)