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Can I read The osteoarthritis bone score (OABS): a new histological scoring system for the characterisation of bone marrow lesions in osteoarthritis on EtoBox?
The osteoarthritis bone score (OABS): a new histological scoring system for the characterisation of bone marrow lesions in osteoarthritis by S. Koushesh; S.M. Shahtaheri; D.F. McWilliams; D.A. Walsh; M.N. Sheppard; J. Westaby; S.M. Haybatollahi; F.A. Howe; N. Sofat is a Medicine article available to read on EtoBox.
What is The osteoarthritis bone score (OABS): a new histological scoring system for the characterisation of bone marrow lesions in osteoarthritis about?
## Objectives: Bone marrow lesions (bmls) are associated with pain in osteoarthritis (oa), but histological scores for oa focus on cartilage pathology. we developed a new scoring system, the osteoarthritis bone score (oabs), to characterise oa-related bmls. ## Methods: Bml/non-bml tissues identified by magnetic resonance imaging (mri) in 10 knee oa subjects were harvested at total knee replacement (tkr). osteochondral tissue from a further 140 tkr and 23 post-mortem (pm) cases was assessed. histological features distinguishing mri-defined bml/non-bml tissues on qualitative analysis were classified as present (0) or absent (1), summated for the oabs, validated by rasch analysis and sensitivity to distinguish between sample groups. immunohistochemistry for pgp9.5 assessed innervation. ## Results: Subchondral characteristics associated with bml tissues were cysts, fibrosis, hypervascularity, cartilage islands, trabecular thickening, loss of tidemark integrity and inflammatory cell infiltration. pgp9.5 immunoreactive perivascular nerves were associated with bmls. oabs performed well as a measurement tool, displayed good reliability (cronbach alpha = 0.68), had a 2-factor structure (tra
Who reads The osteoarthritis bone score (OABS): a new histological scoring system for the characterisation of bone marrow lesions in osteoarthritis?
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- Author
- S. Koushesh; S.M. Shahtaheri; D.F. McWilliams; D.A. Walsh; M.N. Sheppard; J. Westaby; S.M. Haybatollahi; F.A. Howe; N. Sofat
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)