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Can I read The Effect of 6-Hydroxy-2,2,4-Trimethyl-1,2-Dihydroquinoline on the Intensity of Free Radical Processes and Activity of Oxidative Metabolism Enzymes in Rats with Toxic Liver Injury on EtoBox?
The Effect of 6-Hydroxy-2,2,4-Trimethyl-1,2-Dihydroquinoline on the Intensity of Free Radical Processes and Activity of Oxidative Metabolism Enzymes in Rats with Toxic Liver Injury by Brazhnikova, D. A.; Popova, T. N.; Krylâskii, E. D.; Shulgin, K. K.; Matasova, L. V.; Shikhaliev, H. S.; Popov, S. S. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The Effect of 6-Hydroxy-2,2,4-Trimethyl-1,2-Dihydroquinoline on the Intensity of Free Radical Processes and Activity of Oxidative Metabolism Enzymes in Rats with Toxic Liver Injury about?
The effect of 6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline on markers of hepatocyte cytolysis (aspartate transaminase, alanine transaminase and gamma-glutamyl transpeptidase), parameters reflecting the state of oxidative status (intensity of biochemical luminescence and the content of conjugated dienes), and on activity of oxidative metabolism enzymes (aconitate hydratase, glucose-6-phosphate dehydrogenase, NADP-isocitrate dehydrogenase) was studied in rats with CCl 4 -induced liver injury. The results obtained in the course of this study demonstrate the ability of the test compound to reduce oxidative stress severity and the degree of liver cell damage, as well as to change activity of aconitate hydratase and NADP-generating enzymes towards control values. 6-Hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline was more effective in normalizing CCl 4 -induced changes of most analyzed parameters than carsil used as a reference compound. The tendency to normalize the state of oxidative status and enzyme activity of oxidative metabolism can be attributed to hepatoprotective and antioxidant properties of the test compound.
Who reads The Effect of 6-Hydroxy-2,2,4-Trimethyl-1,2-Dihydroquinoline on the Intensity of Free Radical Processes and Activity of Oxidative Metabolism Enzymes in Rats with Toxic Liver Injury?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Brazhnikova, D. A.; Popova, T. N.; Krylâskii, E. D.; Shulgin, K. K.; Matasova, L. V.; Shikhaliev, H. S.; Popov, S. S.
- Publisher
- Pleiades Publishing; Pleiades Publishing Ltd (ISSN 1990-7508)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)