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Thyroid stimulating hormone (TSH) concentrations and menopausal status in women at the mid-life: SWAN by MaryFran Sowers; Judy Luborsky; Craig Perdue; Katy L. B. Araujo; Marlene B. Goldman; Siobán D. Harlow is a Medicine article available to read on EtoBox.

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## Summary **objective** We evaluated menopausal symptoms, menstrual cycle bleeding characteristics and reproductive hormones for their associations with thyroid stimulating hormone (TSH) concentrations in women at the mid‐life from five ethnic groups. **methods** This report is from the baseline evaluation of the Study of Women's Health Across the Nation (SWAN), a community‐based multiethnic study of the natural history of the menopausal transition. Enrollees were 42–52 years old (pre‐ and early perimenopausal) African American, Caucasian, Chinese, Hispanic and Japanese women (__n__ = 3242). Enrollees were interviewed about self‐reported diagnosed hypo‐ and hyperthyroidism or thyroid treatment, menopausal symptoms and menstrual cycle bleeding characteristics. Serum was assayed for TSH, oestradiol, testosterone, FSH and SHBG. **results** There were 6·2% of women with TSH > 5·0 mIU/ml and 3·2% with TSH 5·0 mIU/ml (__P__ < 0·008) or < 0·5 mIU/ml (__P__ < 0·02). Women with TSH values outside the range of 0·5–5·0 mIU/ml were more likely to report shorter or longer menstrual periods (__P__ = 0·004 for both) than women within that range. FSH, SHBG, dehydroepiandrosterone sulphate (DHEA

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Author

MaryFran Sowers; Judy Luborsky; Craig Perdue; Katy L. B. Araujo; Marlene B. Goldman; Siobán D. Harlow

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)

Published

2003

Language

EN

Field

Medicine (Health Sciences)