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Can I read Gastrointestinal Host-pathogen Interaction in the Age of Microbiome Research on EtoBox?
Gastrointestinal Host-pathogen Interaction in the Age of Microbiome Research by Renée M Tsolis; Andreas J Bäumler is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Gastrointestinal Host-pathogen Interaction in the Age of Microbiome Research about?
The microbiota is linked to human health by governing susceptibility to infection. However, the interplay between enteric pathogens, the host, and its microbiota is complex, encompassing host cell manipulation by virulence factors, immune responses, and a diverse gut ecosystem. The host represents a foundation species that uses its immune system as a habitat filter to shape the gut microbiota. In turn, the gut microbiota protects against ecosystem invasion by opportunistic pathogens through priority effects that are based on niche modification or niche preemption. Frank pathogens can overcome these priority effects by using their virulence factors to manipulate host-derived habitat filters, thereby constructing new nutrient-niches in the intestinal lumen that support ecosystem invasion. The emerging picture identifies pathogens as ecosystem engineers and suggests that virulence factors are useful tools for identifying host-derived habitat filters that balance the microbiota.
Who reads Gastrointestinal Host-pathogen Interaction in the Age of Microbiome Research?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Renée M Tsolis; Andreas J Bäumler
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)