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The Influence of Zinc Sulfate on Neonatal Jaundice: a Systematic Review and Meta-analysis by Li Yang; De Wu; Baotian Wang; Xiaosong Bu; Jiulai Tang is a Medicine article available to read on EtoBox.

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## Introduction: Zinc sulfate may be a promising approach to treat neonatal jaundice. however, the results remain controversial. we conducted a systematic review and meta-analysis to evaluate the efficacy and safety of zinc sulfate on hyperbilirubinemia among neonates. ## Methods: Pubmed, embase, web of science, ebsco, cochrane library databases, ovid, bmj database, and cinahl were systematically searched. randomized controlled trials (rcts) assessing the effect of zinc sulfate versus placebo on the prevention of jaundice in neonates were included. two investigators independently searched articles, extracted data, and assessed the quality of included studies. the primary outcomes were total serum bilirubin (tsb) on three days and seven days, the incidence of hyperbilirubinemia. meta-analysis was performed using random- or fixed-effect models. ## Results: Five rcts involving 645 patients were included in the meta-analysis. overall, compared with placebo, zinc sulfate supplementation failed to significantly reduce tsb on three days (mean difference (md) = 0.09 mg/dl; 95% confidence interval (ci) = -0.49 to 0.67; p = .77), tsb on seven days (md = -0.37 mg/dl; 95% ci = -98 to 0.25; p =

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Author

Li Yang; De Wu; Baotian Wang; Xiaosong Bu; Jiulai Tang

Publisher

Informa UK Limited

Published

2017

Language

EN

Field

Medicine (Health Sciences)