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What is AXL Signaling Enhances Cancer Metastasis about?

This study found that the receptor tyrosine kinase AXL confers cell migration and invasion by phosphorylating a network of focal adhesion proteins. Specifically, AXL phosphorylates NEDD9, leading to its binding to CRKII which associates with and phosphorylates the pseudo-kinase PEAK1. PEAK1 is then found to be in a complex with the tyrosine kinase CSK to mediate the phosphorylation of PAXILLIN, resulting in faster disassembly of focal adhesions. Disrupting this PEAK1-mediated signaling pathway decreases met

Author

Albert Tesoro Silang Jr.

Language

EN