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Can I read CD154-CD40 interactions drive hepatocyte apoptosis in murine fulminant hepatitis on EtoBox?
CD154-CD40 interactions drive hepatocyte apoptosis in murine fulminant hepatitis by Feng Zhou; Maureen N. Ajuebor; Paul L. Beck; Tai Le; Cory M. Hogaboam; Mark G. Swain is a Medicine article available to read on EtoBox.
What is CD154-CD40 interactions drive hepatocyte apoptosis in murine fulminant hepatitis about?
The CD154 -CD40 interaction is a critical costimulatory pathway modulating the cellular immune response. Moreover, fulminant hepatitis of various etiologies is characterized by a hepatic influx of CD154-expressing T cells and an upregulation of CD40 expression on Kupffer cells and hepatocytes, implicating this pathway in the pathogenesis of fulminant hepatitis. In this study, we used a murine model of fulminant hepatitis induced by concanavalin A (con A) and documented a significant influx of CD154-expressing T cells into the livers of mice treated with con A, in association with markedly increased expression of CD40 restricted mainly to hepatocytes in damaged areas of the liver. Furthermore, con A hepatitis in CD154-deficient mice was significantly attenuated compared with that in wildtype controls and was associated with a decrease in hepatic tumor necrosis factor ␣ (TNF-␣) levels and hepatocyte death. We next determined the role of the CD154 -CD40 pathway in hepatocyte death in vitro. These in vitro studies demonstrated that TNF-␣ induces CD40 expression in hepatocytes and that subsequent activation of CD40 results in hepatocyte apoptosis mediated at least in part by enhanced he
Who reads CD154-CD40 interactions drive hepatocyte apoptosis in murine fulminant hepatitis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Feng Zhou; Maureen N. Ajuebor; Paul L. Beck; Tai Le; Cory M. Hogaboam; Mark G. Swain
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)