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Effects of Branched-chain Amino Acid Infusion on Protein Metabolism in Rats with Acute Hepatic Failure by Yoshiyuki Miwa; Masahiko Kato; Hisataka Moriwaki; Masataka Okuno; Jun'ichi Sugihara; Horoo Ohnishi; Takashi Yoshida; Professor & Chairman Yasutoshi Muto; Mitsuo Nakayama; Yujiro Morioka; Kouzou Asagi is a Medicine article available to read on EtoBox.
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Branched-chain amino acids (BCAA) are known to improve hepatic encephalopathy as well as protein malnutrition in cirrhosis. However, such effects in acute hepatic failure (AHF) remain to be elucidated. The current study was conducted to investigate whether BCAA improves protein metabolism in AHF. AHF was induced in male Donryu rats weighing approximately 230 g by giving 60 mgkg lipopolysaccaride intravenously and 800 mgkg D-galactosamine hydrochloride intraperitoneally. From 18 hours after injection, AHF rats and control rats were given one of the following five solutions intravenously for 6 hours: 1) saline, 2) lWo glucose, 3) standard 10% amino acid formula with total nitrogen content of 12.2 g/L and BCMaromatic amino acid molar ratio of 37.05, 4) BCAA-enriched solution with nitrogen content of 21.9 g/L and the ratio of 148.2, or 5) an active placebo against BCAA-enriched solution with nitrogen content of 21.9 g/L and the ratio of 37.05. In parallel, each group was given a continuous idksion of W-leucine. After the plasma radioactivity of 14C-leucine and the expired 14C02 level reached a plateau, protein turnover was analyzed according to the kinetic model proposed previously by
Who reads Effects of Branched-chain Amino Acid Infusion on Protein Metabolism in Rats with Acute Hepatic Failure?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Yoshiyuki Miwa; Masahiko Kato; Hisataka Moriwaki; Masataka Okuno; Jun'ichi Sugihara; Horoo Ohnishi; Takashi Yoshida; Professor & Chairman Yasutoshi Muto; Mitsuo Nakayama; Yujiro Morioka; Kouzou Asagi
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 1995
- Language
- EN
- Field
- Medicine (Health Sciences)