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Tri‐layered Alginate/poly( ε ‐Caprolactone) Electrospun Scaffold for Cardiac Tissue Engineering by Seyed Nasir Hosseini Karimi; Rouhollah Mehdinavaz Aghdam; S. A. Seyyed Ebrahimi; Yalda Chehrehsaz is a Materials Science article available to read on EtoBox.

What is Tri‐layered Alginate/poly( ε ‐Caprolactone) Electrospun Scaffold for Cardiac Tissue Engineering about?

## Abstract Novel tri‐layered electrospun alginate–graphene oxide (GO)/poly(ε‐caprolactone) (PCL) conductive scaffolds were fabricated with a sequential electrospinning method for the first time, in which the middle PCL layer acts as a mechanical support of the scaffold. The top and bottom alginate–GO nanofibrous layers provide cell viability and attachment, and also electroconductivity for the scaffold. The fabrication of this nanofibrous scaffold aims to simulate cardiac extracellular matrix. Scanning electron microscopy and infrared spectroscopy were used to characterize the nanofibrous scaffolds, confirming the presence of GO in nanofibers and also crosslinking reaction of the alginate nanofibrous layer. The electroconductivity of the tri‐layered electrospun scaffolds reached 7.29 ± 0.91 μS with the incorporation of 1 wt% GO into the top and bottom alginate nanofibrous layers. The ultimate tensile strength and Young’s modulus of the alginate–0.5 wt% GO/PCL scaffold reached 22.46 ± 0.07 and 4.35 ± 0.56 MPa, respectively. The biocompatibility of the nanofibrous scaffolds was evaluated using cardiac progenitor cells. The results showed that the presence of GO accelerated the degra

Who reads Tri‐layered Alginate/poly( ε ‐Caprolactone) Electrospun Scaffold for Cardiac Tissue Engineering?

Author

Seyed Nasir Hosseini Karimi; Rouhollah Mehdinavaz Aghdam; S. A. Seyyed Ebrahimi; Yalda Chehrehsaz

Publisher

Wiley

Published

2022

Language

EN

Field

Materials Science (Physical Sciences)