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Monocrystalline iron oxide nanocompounds (MION): Physicochemical properties by Tueng Shen; Ralph Weissleder; Mikhail Papisov; Alexei Bogdanov Jr.; Thomas J. Brady is a Medicine article available to read on EtoBox.

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## Abstract We have previously described a novel monocrystalline iron oxide nanocompound (MION), a stable colloid that enables target specific MR imaging. In this study, the physicochemical properties of MION are reported using a variety of analytical techniques. High resolution electron microscopy indicates that a MION consists of hexagonal shaped electron‐dense cores of 4.6 ± 1.2 nm in diameter. This iron oxide core has an inverse spinel crystal structure which was confirmed by x‐ray powder diffraction. Chemical analysis showed that each core has 25 ± 6 dextran molecules (10 kD) attached, resulting in a unimodal hydrodynamic radius of 20 nm by laser light scattering. Because of the flexibillity of the dextran layer, the radius is only 8 nm in nonaqueous reverse micelles. At room temperature, MION exhibit superparamagnetic behavior with an induced magnetization of 68 emu/g Fe at 1.5 T. Mössbauer studies show that the saturation internal magnetic field is 505 KOe, and blocking temperature is at 100 K. The R1 relaxivity of MION is 16.5 (mM‐sec)‐^1^ and the R2 relaxivity is 34.8 (mM‐sec)‐^1^ in aqueous solution at 37°C and 0.47 T. In vitro phantom studies show that the detectability

Who reads Monocrystalline iron oxide nanocompounds (MION): Physicochemical properties?

Author

Tueng Shen; Ralph Weissleder; Mikhail Papisov; Alexei Bogdanov Jr.; Thomas J. Brady

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

1993

Language

EN

Field

Medicine (Health Sciences)