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The effect of hydroxyapatite in biopolymer-based scaffolds on release of naproxen sodium: CHITOSAN-graft-POLY(ACRYLIC ACID)/n-HAP AS DRUG CARRIER FOR BONE TISSUE ENGINEERING by Vahid Asadian-Ardakani; Samaneh Saber-Samandari; Saeed Saber-Samandari is a Engineering article available to read on EtoBox.

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A scaffold capable of controlling drug release is highly desirable for bone tissue engineering. The objective of this study was to develop and characterize a highly porous biodegradable scaffold and evaluate the kinetic release behavior for the application of anti-inflammatory drug delivery. Porous scaffolds consisting of chitosan, poly(acrylic acid), and nano-hydroxyapatite were prepared using the freeze-drying method. The nanocomposite scaffolds were characterized for structure, pore size, porosity, and mechanical properties. The nanocomposite scaffolds were tested and characterized using Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), energy-dispersive analysis of X-ray (EDS), X-ray diffraction (XRD) analysis, and tensile test instrument. The results showed that the pores of the scaffolds were interconnected, and their sizes ranged from 145 μm to 213 μm. The mechanical properties were found close to those of trabecular bone of the same density. The ability of the scaffolds to deliver naproxen sodium as a model drug in vitro was investigated. The release profile of naproxen sodium was measured in a phosphate-buffered saline solution by a ultra-

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Author

Vahid Asadian-Ardakani; Samaneh Saber-Samandari; Saeed Saber-Samandari

Publisher

Wiley

Published

2016

Language

EN

Field

Engineering (Physical Sciences)