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Contribution of hepatic adenosine A1 receptors to renal dysfunction associated with acute liver injury in rats by Zhi Ming; Yi-Jun Fan; Xi Yang; W. Wayne Lautt is a Medicine article available to read on EtoBox.

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Acute liver injury is associated with renal insufficiency, whose mechanism may be related to activation of the hepatorenal reflex. We previously showed that intrahepatic adenosine is involved in activation of the hepatorenal reflex to restrict urine production in both healthy rats and in rats with cirrhosis. The aim of the present study was to test the hypothesis that activation of intrahepatic adenosine receptors is involved in the pathogenesis of the renal insufficiency seen in acute liver injury. Acute liver injury was induced by intraperitoneal injection of thioacetamide (TAA, 500 mg/kg) in rats. The animals were instrumented 24 hours later to monitor systemic, hepatic, and renal circulation and urine production. Severe liver injury developed following TAA insult, which was associated with renal insufficiency, as demonstrated by decreased (ϳ25%) renal arterial blood flow, a lower (ϳ30%) glomerular filtration rate, and decreased urine production. Further, the increase in urine production following volume expansion challenge was inhibited. Intraportal, but not intravenous, administration of a nonselective adenosine receptor antagonist, 8-phenyltheophylline, improved urine product

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Author

Zhi Ming; Yi-Jun Fan; Xi Yang; W. Wayne Lautt

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2006

Language

EN

Field

Medicine (Health Sciences)