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Gene Polymorphisms of Epidermal Growth Factor Receptor and its Downstream Effector, Interleukin-8, Predict Oxaliplatin Efficacy in Patients with Advanced Colorectal Cancer by Wu Zhang; Jan Stoehlmacher; David J. Park; Dongyun Yang; Erin Borchard; Ji Gil; Denice D. Tsao-Wei; Jim Yun; Michael Gordon; Oliver A. Press; Katrin Rhodes; Susan Groshen; Heinz-Josef Lenz is a Medicine article available to read on EtoBox.

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## Background: Researchers have recently reported an association between the epidermal growth factor receptor (egfr) pathway and platinum-chemotherapy sensitivity in cancer patients. the (ca)(n) repeat polymorphism in intron 1 of the egfr gene has been identified and found to alter egfr expression in vitro as well as in vivo. a higher number of these ca repeats is associated with lower egfr levels, whereas a low number of repeats is associated with higher egfr levels. a second key polymorphism within the egfr pathway (her1 r497k) is a single nucleotide change (g-a) in codon 497 of the egfr gene, which leads to an arginine-lysine substitution in the extracellular domain of subdomain iv. furthermore, interleukin-8 (il-8), recently identified as an egfr downstream effector, plays a vital role in tumor angiogenesis and progression. three other polymorphisms, each related to the il-8 gene, have also been identified as playing a pivotal role in the egfr pathway: t-251a in the promoter region of the il-8 gene, g+2607c in exon 2 of the il-8 receptor cxcr1 gene, and c+785t in exon 11 of the il-8 receptor cxcr2 gene. ## Patients and methods: In this study, we employed a 5'-end 33p-gatp-label

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Author

Wu Zhang; Jan Stoehlmacher; David J. Park; Dongyun Yang; Erin Borchard; Ji Gil; Denice D. Tsao-Wei; Jim Yun; Michael Gordon; Oliver A. Press; Katrin Rhodes; Susan Groshen; Heinz-Josef Lenz

Publisher

CIG Media Group, LP.; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 1533-0028)

Published

2005

Language

EN

Field

Medicine (Health Sciences)