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Differentiation of Sarcoidosis from Tuberculosis by Use of Electron Capture Gas-liquid Chromatography by P. L. Almenoff; J. B. Brooks; A. Johnson; M. Lesser is a Medicine article available to read on EtoBox.

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To explore further the possible etiologic role of mycobacteria in the development of sarcoidosis, we measured free, nonbound tuberculostearic acid (TSA, 10-methyloctadecanoic), a component of mycobacteria, in the sera of subjects with sarcoidosis or active untreated pulmonary tuberculosis and in healthy controls by use of frequency-pulsed electron capture gas-liquid chromatography (FPEC-GLC). The selective analytic system is capable of measuring as little as 15-fmol quantities of free, nonbound TSA in serum and cerebral spinal fluid. We found that TSA was present in the sera of all subjects with Mycobacterium tuberculosis (n = 10) but was undetectable in subjects with sarcoidosis (n = 15) and in healthy controls (n = 15), thereby suggesting that if sarcoidosis is caused by a mycobacterial organism, TSA is not produced or does not gain access to the systemic circulation in quantities sufficient for measurement. However, in the course of the studies we found that a peak, designated pl 1, was elevated in the sera of all subjects with acute sarcoidosis (n = 4). Also, a peak designated p3 was reduced significantly in all subjects with acute and chronic sarcoidosis and absent in subjects

Who reads Differentiation of Sarcoidosis from Tuberculosis by Use of Electron Capture Gas-liquid Chromatography?

Author

P. L. Almenoff; J. B. Brooks; A. Johnson; M. Lesser

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0341-2040)

Published

1996

Language

EN

Field

Medicine (Health Sciences)