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Application of HR-MAS NMR spectroscopy for studying chemotype variations of Withania somnifera (L.) Dunal by S. K. Bharti; Anil Bhatia; S. K. Tewari; O. P. Sidhu; Raja Roy is a Chemistry article available to read on EtoBox.

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## Abstract __Withania somnifera__ (L.) Dunal (Solanaceae), commonly known as __Ashwagandha__, is one of the most valued Indian medicinal plants with a number of pharmaceutical and nutraceutical applications. Metabolic profiling has been performed by HR‐MAS NMR spectroscopy on fresh leaf and root tissue specimens from four chemotypes of __W. somnifera__. The HR‐MAS NMR spectroscopy of lyophilized defatted leaf tissue specimens clearly distinguishes resonances of medicinally important secondary metabolites (withaferin A and withanone) and its distinctive quantitative variability among the chemotypes. A total of 41 metabolites were identified from both the leaf and root tissues of the chemotypes. The presence of methanol in leaf and root tissues of __W. somnifera__ was detected by HR‐MAS NMR spectroscopy. Multivariate principal component analysis (PCA) on HR‐MAS ^1^H NMR spectra of leaves revealed clear variations in primary metabolites among the chemotypes. The results of the present study demonstrated an efficient method, which can be utilized for metabolite profiling of primary and secondary metabolites in medicinally important plants. Copyright © 2011 John Wiley & Sons, Ltd.

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Author

S. K. Bharti; Anil Bhatia; S. K. Tewari; O. P. Sidhu; Raja Roy

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; John Wiley and Sons Ltd; Wiley (ISSN 0749-1581)

Published

2011

Language

EN

Field

Chemistry (Physical Sciences)