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Association of dietary proteins with serum creatinine and estimated glomerular filtration rate in a general population sample: the CHRIS study by Vladimir Vukovic; Essi Hantikainen; Athina Raftopoulou; Martin Gögele; Johannes Rainer; Francisco S. Domingues; Peter P. Pramstaller; Vanessa Garcia-Larsen; Cristian Pattaro is a Medicine article available to read on EtoBox.

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## Background: Diet is known to affect kidney function. however, population-based studies provide contrasting evidence, resulting in a poor understanding of the effect of proteins from specific foods on kidney health. ## Methods: We analyzed the effect of total daily protein intake (tdpi) and source-specific daily protein intake (dpi) on fasting serum creatinine (scr) and estimated glomerular filtration rate (egfr) in the cooperative health research in south tyrol (chris) cross-sectional study (n = 5889), using the galen food frequency questionnaire for tdpi and dpi estimation. we fitted multivariable adjusted mixed models of scr and egfr on tdpi and dpi quartiles (q1-q4) in the overall sample, and after removing individuals with known hypertension, diabetes or chronic kidney disease (ckd). ## Results: Higher tdpi as well as dpi from overall animal sources, fish, and poultry, were associated with higher scr (trend test p, p < 0.01), with larger effect after excluding individuals with known hypertension, diabetes or ckd. the egfr was lower at higher tdpi (q4 vs q1: - 1.6 ml/min/1.73 m; 95% ci - 2.5, - 0.7; p = 3e-4) and dpi from fish (q4 vs q1: - 2.1 ml/min/1.73 m; 95% ci - 2.9, - 1

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Author

Vladimir Vukovic; Essi Hantikainen; Athina Raftopoulou; Martin Gögele; Johannes Rainer; Francisco S. Domingues; Peter P. Pramstaller; Vanessa Garcia-Larsen; Cristian Pattaro

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)