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Neural Selectivity, Efficiency, and Dose Equivalence in Deep Brain Stimulation Through Pulse Width Tuning and Segmented Electrodes by Anderson, Collin J.; Anderson, Daria Nesterovich; Pulst, Stefan M.; Butson, Christopher R.; Dorval, Alan D. is a Neuroscience article available to read on EtoBox.
What is Neural Selectivity, Efficiency, and Dose Equivalence in Deep Brain Stimulation Through Pulse Width Tuning and Segmented Electrodes about?
## Background: Achieving deep brain stimulation (dbs) dose equivalence is challenging, especially with pulse width tuning and directional contacts. further, the precise effects of pulse width tuning are unknown, and recent reports of the effects of pulse width tuning on neural selectivity are at odds with classic biophysical studies. ## Methods: We created multicompartment neuron models for two axon diameters and used finite element modeling to determine extracellular influence from standard and segmented electrodes. we analyzed axon activation profiles and calculated volumes of tissue activated. ## Results: We find that long pulse widths focus the stimulation effect on small, nearby fibers, suppressing distant white matter tract activation (responsible for some dbs side effects) and improving battery utilization when equivalent activation is maintained for small axons. directional leads enable similar benefits to a greater degree. reexamining previous reports of short pulse stimulation reducing side effects, we explore a possible alternate explanation: non-dose equivalent stimulation may have resulted in reduced spread of neural activation. finally, using internal capsule avoidanc
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It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Anderson, Collin J.; Anderson, Daria Nesterovich; Pulst, Stefan M.; Butson, Christopher R.; Dorval, Alan D.
- Publisher
- Elsevier ; Elsevier BV (ISSN 1935-861X)
- Published
- 2020
- Language
- EN
- Field
- Neuroscience (Life Sciences)