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Hepatobiliary Disease Resection in Patients with Advanced Epithelial Ovarian Cancer: Prognostic Role and Optimal Cytoreduction by Violante Di Donato; Andrea Giannini; Ottavia D’Oria; Michele Carlo Schiavi; Anna Di Pinto; Margherita Fischetti; Francesca Lecce; Giorgia Perniola; Francesco Battaglia; Pasquale Berloco; Ludovico Muzii; Pierluigi Benedetti Panici is a Medicine article available to read on EtoBox.
What is Hepatobiliary Disease Resection in Patients with Advanced Epithelial Ovarian Cancer: Prognostic Role and Optimal Cytoreduction about?
## Abstract ## Objective The purpose of this study was to evaluate the feasibility and safety in terms of prognostic significance and perioperative morbidity and mortality of cytoreduction in patients affected by advance ovarian cancer and hepato-biliary metastasis. ## Methods Patients with a least one hepatobiliary metastasis who have undergone surgical treatment with curative intent of were considered for the study. Perioperative complications were evaluated and graded with Accordion severity Classification. Five-year PFS and OS were estimated using the Kaplan–Meier curve. ## Results Sixty-seven (20.9%) patients had at least one metastasis to the liver, biliary tract, or porta hepatis. Forty-four (65.7%) and 23 (34.3%) patients underwent respectively high and intermediate complexity surgery according. Complete cytoreduction was achieved in 48 (71.6%) patients with hepato-biliary disease. In two patients (2.9%) severe complications related to hepatobiliary surgery were reported. The median PFS for the patients with hepato-biliary involvement (RT = 0 vs. RT > 0) was 19 months [95% confidence interval (CI) 16.2–21.8] and 8 months (95% CI 6.1–9.9). The median OS for the patients with
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- Author
- Violante Di Donato; Andrea Giannini; Ottavia D’Oria; Michele Carlo Schiavi; Anna Di Pinto; Margherita Fischetti; Francesca Lecce; Giorgia Perniola; Francesco Battaglia; Pasquale Berloco; Ludovico Muzii; Pierluigi Benedetti Panici
- Publisher
- Springer Science and Business Media LLC
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)