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Local delivery of magnetic resonance (MR) contrast agent in kidney using thermosensitive liposomes and MR imaging-guided local hyperthermia: A feasibility study in vivo by Rares Salomir; Jean Palussière; Sigrid L. Fossheim; Astri Rogstad; Unni N. Wiggen; Nicolas Grenier; Chrit T.W. Moonen is a Medicine article available to read on EtoBox.
What is Local delivery of magnetic resonance (MR) contrast agent in kidney using thermosensitive liposomes and MR imaging-guided local hyperthermia: A feasibility study in vivo about?
## Abstract ## Purpose To investigate the feasibility of local delivery of a magnetic resonance (MR) contrast agent in vivo using paramagnetic thermosensitive liposomes and infrared (IR) laser‐induced local hyperthermia under real‐time MR thermometry on rabbit kidney. ## Materials and Methods Respiratory gated, radio frequency (RF)‐spoiled gradient‐echo sequences were used for precise MR temperature mapping (SD = 1°C). In vivo heating experiments confirmed local release of MR contrast agent from liposomes. ## Results T~1~ decreased from 800 msec to about 500 msec, as measured after tissue cooling, in those locations where the renal parenchyma was heated above the phase transition temperature of the liposome membrane. ## Conclusion The release of MR contrast agent has been demonstrated in rabbit kidney in vivo. This may be used as a reporter for simultaneous release of therapeutic agents. J. Magn. Reson. Imaging 2005. © 2005 Wiley‐Liss, Inc.
Who reads Local delivery of magnetic resonance (MR) contrast agent in kidney using thermosensitive liposomes and MR imaging-guided local hyperthermia: A feasibility study in vivo?
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- Author
- Rares Salomir; Jean Palussière; Sigrid L. Fossheim; Astri Rogstad; Unni N. Wiggen; Nicolas Grenier; Chrit T.W. Moonen
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-1807)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)