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Sema7A protects against high-fat diet-induced obesity and hepatic steatosis by regulating adipo/lipogenesis by Qiongyu Lu; Ziting Liu; Luyao Zhao; Linru Xu; Chu Liu; Ling Li; Yiren Cao; Fengchan Li; Lili Wu; Lei Wang; Ting Chen; Tao You; Lijie Ren; Guixue Wang; Chaojun Tang; Li Zhu is a Medicine article available to read on EtoBox.
What is Sema7A protects against high-fat diet-induced obesity and hepatic steatosis by regulating adipo/lipogenesis about?
## Objective Obesity and related diseases are becoming a growing risk for public health around the world due to the westernized lifestyle. Sema7A, an axonal guidance molecule, has been known to play a role in neurite growth, bone formation, and immune regulation. Whether Sema7A participates in obesity and metabolic diseases is unknown. As several SNPs in __SEMA7A__ and its receptors were found to correlate with BMI and metabolic parameters in the human population, we investigated the potential role of Sema7A in obesity and hepatic steatosis. ## Methods GWAS and GEPIA database was used to analyze SNPs in __SEMA7A__ and the correlation of Sema7A expression with lipid metabolism related genes. Sema7A^−/−^ mice and recombinant Sema7A (rSema7A) were used to study the role of Sema7A in HFD-induced obesity and hepatic steatosis. Adipose tissue-derived mesenchymal stem cells (ADSCs) were used to examine the role of Sema7A in adipogenesis, lipogenesis and downstream signaling. ## Results Deletion of Sema7A aggravated HFD-induced obesity. Sema7A deletion enhanced adipogenesis in both subcutaneous and visceral ADSCs, while the addition of rSema7A inhibited adipogenesis of ADSCs and lipogenesi
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- Author
- Qiongyu Lu; Ziting Liu; Luyao Zhao; Linru Xu; Chu Liu; Ling Li; Yiren Cao; Fengchan Li; Lili Wu; Lei Wang; Ting Chen; Tao You; Lijie Ren; Guixue Wang; Chaojun Tang; Li Zhu
- Publisher
- Elsevier
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)