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The Evaluation of Meropenem Dosing Regimens Against ESBL-Producing Escherichia coli in ICU Patients Using Monte Carlo Simulation by Ei Ei Win; Khaing Win Htun; Pramote Tragulpiankit; Suwida Tangtrakultham; Preecha Montakantikul is a Medicine article available to read on EtoBox.
What is The Evaluation of Meropenem Dosing Regimens Against ESBL-Producing Escherichia coli in ICU Patients Using Monte Carlo Simulation about?
## Purpose To evaluate the optimal dosing regimens of meropenem against extended-spectrum beta-lactamase-producing __Escherichia coli__ (ESBL __E. coli__) in critically ill patients with varying degrees of renal function using Monte Carlo simulation (MCS). ## Methods The MCS was performed using the minimum inhibitory concentration (MIC) data from Right Laboratory and Health Screen in Naypyitaw, Myanmar, as well as reported meropenem pharmacokinetic parameters in the target population and the pharmacokinetic-pharmacodynamic index. For each dosing regimen, 10,000 virtual patients were generated to assess the probability of target attainment (PTA) and the cumulative fraction of response (CFR). The most effective dosage regimens were determined using PTA and a CFR of 90%. ## Results ESBL __E. coli__ made up 93 of the 396 clinical __E. coli__ isolates, and they are all multidrug-resistant, with resistance to at least five antibiotic classes. The MIC~50~ and MIC~90~ were determined to be 0.25 μg/mL. The PTA was affected by five factors: creatinine clearance (CLcr), vasopressor usage, MIC, infusion time, and dosage fractionation. In patients who did not receive vasopressors, the current r
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- Author
- Ei Ei Win; Khaing Win Htun; Pramote Tragulpiankit; Suwida Tangtrakultham; Preecha Montakantikul
- Publisher
- Informa UK Limited
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)