About this Biochemistry, Genetics and Molecular Biology article

Segregation Analysis of Prostate Cancer in France: Evidence for Autosomal Dominant Inheritance and Residual Brother‐brother Dependence by A. Valeri; L. Briollais; R. Azzouzi; G. Fournier; P. Mangin; P. Berthon; O. Cussenot; F. Demenais is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

## Summary Four segregation analyses concerning prostate cancer (CaP), three conducted in the United States and one in Northern Europe, have shown evidence for a dominant major gene but with different parameter estimates. A recent segregation analysis of Australian pedigrees has found a better fit of a two‐locus model than single‐locus models. This model included a dominantly inherited increased risk that was greater at younger ages and a recessively inherited or X‐linked increased risk that was greater at older ages. Recent linkage analyses have led to the detection of at least 8 CaP predisposing genes, suggesting a complex inheritance and genetic heterogeneity. To assess the nature of familial aggregation of prostate cancer in France, segregation analysis was conducted in 691 families ascertained through 691 CaP patients, recruited from three French hospitals and unselected with respect to age at diagnosis, clinical stage or family history. This mode of family inclusion, without any particular selection of the probands, is unique, as probands from all previous analyses were selected according to various criteria. Segregation analysis was carried out using the logistic hazard regr

Author

A. Valeri; L. Briollais; R. Azzouzi; G. Fournier; P. Mangin; P. Berthon; O. Cussenot; F. Demenais

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0003-4800)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)