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Increases in anterograde axoplasmic transport in neurons of the hyper‐glutamatergic, glutamate dehydrogenase 1 ( Glud1 ) transgenic mouse: Effects of glutamate receptors on transport by Phil Lee; Jieun Kim; In‐Young Choi; Ranu Pal; Dongwei Hui; Joanne K. Marcario; Mary L. Michaelis; Elias K. Michaelis is a Neuroscience article available to read on EtoBox.
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## Abstract The excitatory neurotransmitter glutamate has a role in neuronal migration and process elongation in the central nervous system (CNS). The effects of chronic glutamate hyperactivity on vesicular and protein transport within CNS neurons, that is, processes necessary for neurite growth, have not been examined previously. In this study, we measured the effects of lifelong hyperactivity of glutamate neurotransmission on axoplasmic transport in CNS neurons. We compared wild‐type (wt) to transgenic (Tg) mice over‐expressing the glutamate dehydrogenase gene __Glud1__ in CNS neurons and exhibiting increases in glutamate transmitter formation, release, and synaptic activation in brain throughout the lifespan. We found that __Glud1__ Tg as compared with wt mice exhibited increases in the rate of anterograde axoplasmic transport in neurons of the hippocampus measured in brain slices ex vivo, and in olfactory neurons measured __in vivo__. We also showed that the __in vitro__ pharmacologic activation of glutamate synapses in wt mice led to moderate increases in axoplasmic transport, while exposure to selective inhibitors of ion channel forming glutamate receptors very significantly
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- Author
- Phil Lee; Jieun Kim; In‐Young Choi; Ranu Pal; Dongwei Hui; Joanne K. Marcario; Mary L. Michaelis; Elias K. Michaelis
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Neuroscience (Life Sciences)