About this document
Sharma 2018 by Apu kumar Das is a document available to read on EtoBox.
The manuscript investigates the inhibitory and binding characteristics of methyl-sulfone hydroxamate-based inhibitors against LpxC from drug-resistant Moraxella catarrhalis using various biophysical, biochemical, and in silico methods. Key findings include conformational changes in the enzyme upon inhibitor binding and comparable binding affinities for the tested inhibitors. The study suggests potential for further development of these inhibitors as antimicrobial agents targeting LpxC.
- Author
- Apu kumar Das
- Language
- EN