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Phase-Transfer-Catalyzed Asymmetric Synthesis of ChiralN-Substituted Pyr­azoles by Aza-Michael Reaction: Phase-Transfer-Catalyzed Asymmetric Synthesis ofN-Substituted Pyrazoles by Su-Jeong Lee; Ju-Yeon Bae; Chang-Woo Cho is a Chemistry article available to read on EtoBox.

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An efficient cinchona-based phase-transfer-catalyzed asymmetric aza-Michael reaction of pyrazole with various α,β-unsaturated ketones has been developed for the preparation of chiral N-substituted pyrazoles. This reaction provided the desired products in good yields (up to 99 %) with excellent enantioselectivities (87-94 % ee). In addition, the reaction of [a

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Author

Su-Jeong Lee; Ju-Yeon Bae; Chang-Woo Cho

Published

2015

Language

EN

Field

Chemistry (Physical Sciences)