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Inter-α-inhibitor heavy chain H4 and sepsis-related coagulation disturbances: Another link between innate immunity and coagulation by Julie Brogaard Larsen; Rasmus Pihl; Mathies Appel Aggerbeck; Kim Michael Larsen; Christine Lodberg Hvas; Nanna Johnsen; Mette G. Christensen; Helle Praetorius; Anne-Mette Hvas; Steffen Thiel is a Medicine article available to read on EtoBox.
What is Inter-α-inhibitor heavy chain H4 and sepsis-related coagulation disturbances: Another link between innate immunity and coagulation about?
## Background The protease inhibitor inter-α-inhibitor heavy chain H4 (ITIH4) has been described as an acute-phase reactant and could potentially aid in sepsis monitoring and prognostication. ## Objectives To investigate ITIH4 plasma levels in sepsis patients compared with healthy controls and to examine the association between ITIH4 and acute-phase response markers, blood coagulation, and organ dysfunction in sepsis. ## Methods We performed a post hoc study to a prospective cohort study. Patients with septic shock (n = 39) were enrolled upon intensive care unit admission. ITIH4 was analyzed using an in-house immunoassay. Standard coagulation parameters, thrombin generation, fibrin formation and lysis, C-reactive protein, organ dysfunction markers, Sequential Organ Failure Assessment score, and disseminated intravascular coagulation (DIC) score were registered. ITIH4 levels were also investigated in a murine __Escherichia coli__ sepsis model. ## Results ITIH4 did not display acute-phase behavior as mean ITIH4 levels were not increased in patients with septic shock or in __E. coli__-infected mice. However, ITIH4 exhibited large interindividual variation in patients with septic shock
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- Author
- Julie Brogaard Larsen; Rasmus Pihl; Mathies Appel Aggerbeck; Kim Michael Larsen; Christine Lodberg Hvas; Nanna Johnsen; Mette G. Christensen; Helle Praetorius; Anne-Mette Hvas; Steffen Thiel
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)