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What is Vasoactive Intestinal Peptide Has A Direct about?

The study investigates the positive inotropic effects of vasoactive intestinal peptide (VIP) on isolated human myocardial trabeculae from both the right atrium and left ventricle. VIP demonstrated a significant positive inotropic effect, which was inhibited by the VIP-receptor antagonist VIP-(6–28), and the presence of mRNAs for the three cloned human VIP receptors (VPAC1, VPAC2, PAC1) was confirmed. These findings suggest that VIP directly enhances contractility in human heart tissues via these receptors.

Author

pagasablo

Language

EN