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Assessment of Angiogenic Potential of Mesenchymal Stem Cells Derived Conditioned Medium from Various Oral Sources by Madhura Rajendra Shekatkar; Supriya Mohit Kheur; Avinash Haribhau Kharat; Shantanu Sanjeev Deshpande; Avinash Purushottam Sanap; Mohit Gurunath Kheur; Ramesh Ramchandra Bhonde is a scholarly article available to read on EtoBox.

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## Background: Abnormal angiogenesis hamper blood vessel proliferation implicated in various biological processes. The current method available to clinically treat patients to enhance angiogenesis is administering the angiogenic growth factors. However, due to a lack of spatiotemporal control over the substantial release of these factors, numerous drawbacks are faced such as leaky vasculature. Hence, stem-cell-based therapeutic applications are running their race to evolve as potential targets for deranged angiogenesis. In clinical dentistry, adequate tissue vascularization is essential for successful endodontic therapies such as apexogenesis and apexification. Furthermore, wound healing of the extraction socket and tissue regeneration post-surgical phase of treatment including implant placement require angiogenesis as a foundation for the ultimate success of treatment. Mesenchymal stem cells (MSCs) secrete certain growth factors and cytokines in the culture medium during the proliferation. These factors and cytokines are responsible for various biological activities inside human body. Oral cavity-derived stem cells can secrete growth factors that enhance angiogenesis. ## Aim: The

Author

Madhura Rajendra Shekatkar; Supriya Mohit Kheur; Avinash Haribhau Kharat; Shantanu Sanjeev Deshpande; Avinash Purushottam Sanap; Mohit Gurunath Kheur; Ramesh Ramchandra Bhonde

Published

2022