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Treatment of agnogenic myeloid metaplasia with danazol: A report of four cases by Lévy, V.; Bourgarit, A.; Delmer, A.; Legrand, O.; Baudard, M.; Rio, B.; Zittoun, R. is a Medicine article available to read on EtoBox.
What is Treatment of agnogenic myeloid metaplasia with danazol: A report of four cases about?
Peripheral cytopenias are common in patients with agnogenic myeloid metaplasia (AMM). They are an important cause of morbidity and mortality, and their treatment is difficult. We report on 4 patients with AMM and severe cytopenia treated with danazol (400-600 mg/ day). Three of them became independent of red blood cell (RBC) transfusion, while the other had a slight reduction in RBC requirement. In addition, correction of thrombocytopenia and disappearance of splenomegaly were observed in 1 and 2 patients, respectively. No side effects were observed. In our experience, danazol appears effective and safe in the subset of patients with AMM whose disease is mainly characterized by bone-marrow failure. These data warrant further studies to evaluate this treatment and explore its mechanism of action.
Who reads Treatment of agnogenic myeloid metaplasia with danazol: A report of four cases?
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- Author
- Lévy, V.; Bourgarit, A.; Delmer, A.; Legrand, O.; Baudard, M.; Rio, B.; Zittoun, R.
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0361-8609)
- Published
- 1996
- Language
- EN
- Field
- Medicine (Health Sciences)