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Can I read Terminal C(sp ^3^ )–H borylation through intermolecular radical sampling on EtoBox?
Terminal C(sp ^3^ )–H borylation through intermolecular radical sampling by Miao Wang; Yahao Huang; Peng Hu is a Medicine article available to read on EtoBox.
What is Terminal C(sp ^3^ )–H borylation through intermolecular radical sampling about?
Hydrogen atom transfer (HAT) processes can overcome the strong bond dissociation energies (BDEs) of inert C(sp ^3^ )–H bonds and thereby convert feedstock alkanes into value-added fine chemicals. Nevertheless, the high reactivity of HAT reagents, coupled with the small differences among various C(sp ^3^ )–H bond strengths, renders site-selective transformations of straight-chain alkanes a great challenge. Here, we present a photocatalytic intermolecular radical sampling process for the iron-catalyzed borylation of terminal C(sp ^3^ )–H bonds in substrates with small steric hindrance, including unbranched alkanes. Mechanistic investigations have revealed that the reaction proceeds through a reversible HAT process, followed by a selective borylation of carbon radicals. A boron-sulfoxide complex may contribute to the high terminal regioselectivity observed.
Who reads Terminal C(sp ^3^ )–H borylation through intermolecular radical sampling?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Miao Wang; Yahao Huang; Peng Hu
- Publisher
- American Association for the Advancement of Science (AAAS)
- Published
- 2024
- Language
- EN
- Field
- Medicine (Social Sciences)