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Aspirin/hydroxycarbamide ## Lack of efficacy: case report A 75-year-old man exhibited lack of efficacy following cytoreductive treatment with hydroxycarbamide and aspirin. The man, presented to the hospital with a history of sudden onset of painless vision loss in the right eye. He had a history of recent jaw claudication and weight loss. The visual loss developed suddenly 5 days prior to his presentation. His medical history was significant for hypertension, hyperlipidaemia, ischaemic stroke and a 40 pack/year smoking history. His right eye visual acuity was reduced to hand movements and 6/7.5 in the left eye. Subsequent examination results were suggestive of central retinal artery occlusion (CRAO) and giant cell arteritis (GCA). He also exhibited thrombocytosis. He started receiving empiric treatment with methylprednisolone followed by prednisolone. Based on susbsequent artery biopsy results, GCA was confirmed, while bone marrow biopsy showed changes indicative of primary myelofibrosis. He started receiving cytoreductive treatment with hydroxycarbamide [hydroxyurea] along with low-dose aspirin [dosage and route not stated]. However, there was no improvement in visual acuity after

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Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)