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Serotonergic signalling between thyroid cells: Protein kinase C and 5‐HT~2~ receptors in the secretion and action of serotonin by Dr. Hadassah Tamir; Shu-Chi Hsiung; Pei-Ying Y. Yu; Kuo-Peing Liu; Mella Adlersberg; Eladio A. Nunez; Michael D. Gershon is a Neuroscience article available to read on EtoBox.

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## Abstract Parafollicular (PF) cells of the thyroid gland are neural crest derivatives, which costore the neurotransmitter, 5‐hydroxytryptamine (5‐HT) with calcitonin. PF cells are located adjacent to follicular (F) cells within the basement membrane of thyroid follicles. It has been proposed that 5‐HT serves an intercellular signalling function in the thyroid and that F cells are its target. This proposal was tested by using cell lines derived from PF (medullary thyroid carcinoma [MTC]) and F (FRTL‐5) cells to study the mechanisms that mediate the secretion and action of 5‐HT. Secretion of 5‐HT by MTC cells was evoked by thyroid stimulating hormone, thyrotropin (TSH), elevated extracellular calcium (↑[Ca^2+^]~e~), or by agents that increase intracellular cAMP (↑[cAMP]~i~). When protein kinase C (PKC) was down‐regulated by prolonged treatment of MTC cells with phorbol 12‐myristate 13‐acetate (PMA), or PKC was inhibited by staurosporin, the TSH‐or PMA‐evoked secretion of 5‐HT was blocked; however, interference with PKC function did not affect 5‐HT secretion evoked by ↑ [Ca^2+^]~e~ or ↑ [cAMP]~i~. In the putative targets, FRTL‐5 cells, 5‐HT increased the turnover of phosphoinositide

Who reads Serotonergic signalling between thyroid cells: Protein kinase C and 5‐HT~2~ receptors in the secretion and action of serotonin?

Author

Dr. Hadassah Tamir; Shu-Chi Hsiung; Pei-Ying Y. Yu; Kuo-Peing Liu; Mella Adlersberg; Eladio A. Nunez; Michael D. Gershon

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)

Published

1992

Language

EN

Field

Neuroscience (Life Sciences)