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Effect of Age-dependent Exposure to Lead on Hepatotoxicity and Nephrotoxicity in Male Rats by Alya Annabi Berrahal; Montassar Lasram; Naziha El Elj; Abdelhamid Kerkeni; Najoua Gharbi; Saloua El-Fazâa is a Environmental Science article available to read on EtoBox.
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## Abstract Lead is known to induce a broad range of physiological, biochemical, and behavioral dysfunctions in laboratory animals and humans. This includes age‐specific variations in absorption, retention, and tissue distribution of lead. This study was carried out to investigate the effects of chronic exposure to lead (50 mg/L) on liver and kidneys of two different age groups of male rats treated with lead from delivery until puberty period (40 days) and postpuberty period (65 days). For this purpose, the concentrations of thiobarbituric acid reactive substance (TBARS), total thiol groups (SH), and superoxide dismutase (SOD) activity were measured in the liver and kidney of rats. Renal function was analyzed by determining creatinine, acid uric, and urea. Plasma activities of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and albumin were determined spectrophotometrically to evaluate hepatic function. These markers of damage were determined to assess the level of toxicity in these animals. Our results clearly show that the administration of lead produces oxidative damage in liver and kidney, as strongly suggested by the significant increase in TBARS, d
Who reads Effect of Age-dependent Exposure to Lead on Hepatotoxicity and Nephrotoxicity in Male Rats?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Alya Annabi Berrahal; Montassar Lasram; Naziha El Elj; Abdelhamid Kerkeni; Najoua Gharbi; Saloua El-Fazâa
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1520-4081)
- Published
- 2011
- Language
- EN
- Field
- Environmental Science (Physical Sciences)