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Scalp Ripples as Prognostic Biomarkers of Epileptogenicity in Pediatric Surgery by Tamilia, Eleonora; Dirodi, Matilde; Alhilani, Michel; Grant, P. Ellen; Madsen, Joseph R.; Stufflebeam, Steven M.; Pearl, Phillip L.; Papadelis, Christos is a Medicine article available to read on EtoBox.
What is Scalp Ripples as Prognostic Biomarkers of Epileptogenicity in Pediatric Surgery about?
## Abstract ## Objective To assess the ability of high‐density Electroencephalography (HD‐EEG) and magnetoencephalography (MEG) to localize interictal ripples, distinguish between ripples co‐occurring with spikes (ripples‐on‐spike) and independent from spikes (ripples‐alone), and evaluate their localizing value as biomarkers of epileptogenicity in children with medically refractory epilepsy. ## Methods We retrospectively studied 20 children who underwent epilepsy surgery. We identified ripples on HD‐EEG and MEG data, localized their generators, and compared them with intracranial EEG (icEEG) ripples. When ripples and spikes co‐occurred, we performed source imaging distinctly on the data above 80 Hz (to localize ripples) and below 70 Hz (to localize spikes). We assessed whether missed resection of ripple sources predicted poor outcome, separately for ripples‐on‐spikes and ripples‐alone. Similarly, predictive value of spikes was calculated. ## Results We observed scalp ripples in 16 patients (10 good outcome). Ripple sources were highly concordant to the icEEG ripples (HD‐EEG concordance: 79%; MEG: 83%). When ripples and spikes co‐occurred, their sources were spatially distinct in 83
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- Author
- Tamilia, Eleonora; Dirodi, Matilde; Alhilani, Michel; Grant, P. Ellen; Madsen, Joseph R.; Stufflebeam, Steven M.; Pearl, Phillip L.; Papadelis, Christos
- Publisher
- Wiley (John Wiley & Sons); John Wiley and Sons Inc.; Wiley (ISSN 2328-9503)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)