Can I read Effect of Methylglyoxal Bisguanylhydrazone on Polyamine Biosynthesis, Growth, and Differentiation of Cultured Keratinocytes on EtoBox?
Effect of Methylglyoxal Bisguanylhydrazone on Polyamine Biosynthesis, Growth, and Differentiation of Cultured Keratinocytes by Michael S. Proctor; Su -Chin C. Liu; David I. Wilkinson is a Medicine article available to read on EtoBox.
What is Effect of Methylglyoxal Bisguanylhydrazone on Polyamine Biosynthesis, Growth, and Differentiation of Cultured Keratinocytes about?
The putrescine, spermidine, and spermine content of subcultured human newborn foreskin keratinocytes was determined during growth and early plateau phase and found to be highest during growth. Exposure of the cells to methylglyoxal bis(guanylhydrazone) during growth phase caused a dosedependent fall in intracellular spermidine and spermine levels and an increase in putrescine levels at higher concentrations. These effects reflect inhibition of Sadenosyl methionine decarboxylase by the drug. At 8 x 10-6M the drug reduced incorporation of leucine into protein, lowered or stopped the accumulation of DNA per dish, inhibited mitotic activity, and increased the histidine/leucine incorporation into protein. The last effect is regarded as induction of keratinization. All these effects were reversible if the use of the drug was discontinued after 3 days. Inhibition of the enzymes of polyamine biosynthesis may have value in psoriasis therapy.
Who reads Effect of Methylglyoxal Bisguanylhydrazone on Polyamine Biosynthesis, Growth, and Differentiation of Cultured Keratinocytes?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Michael S. Proctor; Su -Chin C. Liu; David I. Wilkinson
- Publisher
- Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0340-3696)
- Published
- 1980
- Language
- EN
- Field
- Medicine (Health Sciences)