Can I read Mass balance and metabolism of aclidinium bromide following intravenous administration of [14C]-aclidinium bromide in healthy subjects: ACLIDINIUM MASS BALANCE AND METABOLISM IN HEALTHY SUBJECTS on EtoBox?

Mass balance and metabolism of aclidinium bromide following intravenous administration of [14C]-aclidinium bromide in healthy subjects: ACLIDINIUM MASS BALANCE AND METABOLISM IN HEALTHY SUBJECTS by Stephan Ortiz; Stephen Flach; John Ho; Fanying Li; Cynthia F. Caracta; Esther Garcia Gil; Josep M. Jansat is a Medicine article available to read on EtoBox.

What is Mass balance and metabolism of aclidinium bromide following intravenous administration of [14C]-aclidinium bromide in healthy subjects: ACLIDINIUM MASS BALANCE AND METABOLISM IN HEALTHY SUBJECTS about?

Aclidinium bromide is a novel, inhaled long-acting muscarinic antagonist with low systemic activity developed for the treatment of COPD. It is an ester compound rapidly hydrolysed in plasma into inactive alcohol and acid metabolites. In this Phase I, open-label study, the rates and routes of elimination of radioactivity following intravenous administration of [ 14 C]-aclidinium bromide were determined. The metabolites of aclidinium were also characterized and identified in plasma and excreta. Twelve healthy males were randomized (1:1) to receive a single intravenous 400 mg dose of [phenyl-U-14 C]-or [glycolyl-U-14 C]-aclidinium bromide (via 5 min infusion) to label alcohol or acid metabolites of aclidinium, respectively. Safety and tolerability were assessed over a 9-day period. Following intravenous administration, the parent compound was rapidly hydrolysed into its acid and alcohol metabolites. Primary excretion routes for [phenyl-U-14 C]-and [glycolyl-U-14 C]-aclidinium were renal (urine: 65% and 54%, respectively; feces: 33% and 20%, respectively), with 1% excreted as unchanged aclidinium. A total of three treatment-emergent adverse events in two subjects were reported and were

Who reads Mass balance and metabolism of aclidinium bromide following intravenous administration of [14C]-aclidinium bromide in healthy subjects: ACLIDINIUM MASS BALANCE AND METABOLISM IN HEALTHY SUBJECTS?

Author

Stephan Ortiz; Stephen Flach; John Ho; Fanying Li; Cynthia F. Caracta; Esther Garcia Gil; Josep M. Jansat

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0142-2782)

Published

2012

Language

EN

Field

Medicine (Health Sciences)