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Synthesis of peptide derived amino alcohols II. Synthetic methodology for the preparation of tertiary alcohols by Jollie D. Godfrey Jr.; Eric M. Gordon; Derek J. Von Langen is a Chemistry article available to read on EtoBox.
What is Synthesis of peptide derived amino alcohols II. Synthetic methodology for the preparation of tertiary alcohols about?
Synthetic methods are described for the preparation of a series of tripeptide derived aminoalcohols (i.e., 2). These novel peptidyl tertiary alcohols are potential inhibitors of angiotensin converting enzyme (ACE). The synthetic targets resemble acyltripeptide substrates for the enzyme, but contain a -CHOH(CH3)-CHZ-NH-moiety, as replacement for the scissile amide bond. Recently we described the design' and synthesis2 of a new series of tripeptide derived aminoalcohols, typified by structure L which were shown to be potent inhibitors of angiotensin converting enzyme (ACE).
Who reads Synthesis of peptide derived amino alcohols II. Synthetic methodology for the preparation of tertiary alcohols?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Jollie D. Godfrey Jr.; Eric M. Gordon; Derek J. Von Langen
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4039)
- Published
- 1987
- Language
- EN
- Field
- Chemistry (Physical Sciences)