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Molecular evidence of fetal-derived chromosome 21 markers (STRs) in transcervical samples by Matteo Adinolfi; Jon Sherlock; Peter Soothill; Charles Rodeck is a Medicine article available to read on EtoBox.

What is Molecular evidence of fetal-derived chromosome 21 markers (STRs) in transcervical samples about?

## Abstract Transcervical cells (TCCs), collected by flushing or aspiration at 8–13 weeks of gestation, were analysed for the presence of fetal‐derived DNA sequences. DNA extracted from maternal peripheral blood, TCC samples, and placental tissue was amplified by the polymerase chain reaction (PCR) to detect small tandem repeat (STR) markers specific to chromosome 21. STR products of fetal origin could be clearly observed in four TCC samples. TCC samples collected by flushing or aspiration were also analysed by fluorescent __in situ__ hybridization (FISH) using X and Y probes simultaneously: 46,XY cells could be detected in all TCC samples obtained from mothers with male fetuses.

Who reads Molecular evidence of fetal-derived chromosome 21 markers (STRs) in transcervical samples?

Author

Matteo Adinolfi; Jon Sherlock; Peter Soothill; Charles Rodeck

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0197-3851)

Published

1995

Language

EN

Field

Medicine (Health Sciences)