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Exploring treatment outcomes in Stage II-III rectal cancer patients undergoing neoadjuvant therapy at a tertiary care center in Pakistan: a comprehensive analysis of pathological outcomes by Misbah Younus Soomro; Saqib Raza Khan; Hafiz Muhammad; Sujjawal Ahmad; Nawazish Zehra; Insia Ali; Mirza Rameez Samar; Arif Hameed; Munira Moosajee; Yasmin Abdul Rashid is a Medicine article available to read on EtoBox.

What is Exploring treatment outcomes in Stage II-III rectal cancer patients undergoing neoadjuvant therapy at a tertiary care center in Pakistan: a comprehensive analysis of pathological outcomes about?

## Abstract ## Background Rectal cancer treatment has transformed in recent years, with neoadjuvant treatment (NT) and total neoadjuvant treatment (TNT) aiming to enhance pathological responses. This pioneering study in our country delves into rectal cancer management, offering crucial insights by examining pathological outcomes in patients treated with the NT and TNT approach, shaping the evolving landscape. ## Methods In this retrospective-cohort study spanning January 2017 to December 2022 at a tertiary care hospital in Pakistan, ethical approval was obtained to examine outcomes of two treatments. Patients were divided into TNT (chemoradiation and pre-surgery 5 FU-based chemotherapy) and NT (chemoradiation, surgery, and subsequent 5 FU-based chemotherapy). The primary end-point was response rates—no response, pathological complete response (pCR), near complete response (near CR), and partial response (PR). The Chi-Square Test for Independence assessed the association between treatment response and type (TNT or NT). Data analysis used STATA MP 64; significance was set at __p__ 65 with ECOG 0–1. The TNT group showed higher response rates (76% vs 62%, __p__ = 0.039), with 40.38%

Who reads Exploring treatment outcomes in Stage II-III rectal cancer patients undergoing neoadjuvant therapy at a tertiary care center in Pakistan: a comprehensive analysis of pathological outcomes?

Author

Misbah Younus Soomro; Saqib Raza Khan; Hafiz Muhammad; Sujjawal Ahmad; Nawazish Zehra; Insia Ali; Mirza Rameez Samar; Arif Hameed; Munira Moosajee; Yasmin Abdul Rashid

Publisher

Springer Science and Business Media LLC

Published

2024

Language

EN

Field

Medicine (Health Sciences)