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Acute lymphoblastic leukemia in a patient with type 1 Gaucher disease developing 1 year after discontinuation of enzyme replacement therapy by Aditi Ranade; Sorin Selegean; Gagangeet Sandhu; Violette Ghali; Vijay P. Shah is a Medicine article available to read on EtoBox.

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Higher rates of venous thromboembolism for Black-Americans are likely due to lower serum ## 25-hydroxyvitamin D levels To the editor: The recent paper on disparities of thromboembolism in the United States concluded that heritability may be important in the etiology of venous thromboembolism among Black-Americans [1]. That is correct but not in the manner considered by the authors. As Black-Americans have darker skin than White-Americans, they have lower serum 25-hydoxyvitamin D [25(OH)D] levels, with mean value of 16 ng/mL compared with 26 ng/mL for White-Americans [2]. Lower serum 25(OH)D levels are a risk factor for cardiovascular disease in general [3] and venous thrombotic events in particular [4], as well as Type 2 diabetes mellitus [3]. A recent review concluded that the disparities in serum 25(OH)D levels can account for most of the 25% higher mortality rates for Black-Americans compared with White-Americans [5]. If Black-Americans were to supplement with 2,000-5,000 IU/day of vitamin D3, which would raise serum 25(OH)D levels from a mean value of 16 ng/mL to 30-50 ng/mL, they would significantly reduce their risk of venous thromboembolism, other cardiovascular diseases, Ty

Who reads Acute lymphoblastic leukemia in a patient with type 1 Gaucher disease developing 1 year after discontinuation of enzyme replacement therapy?

Author

Aditi Ranade; Sorin Selegean; Gagangeet Sandhu; Violette Ghali; Vijay P. Shah

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0361-8609)

Published

2010

Language

EN

Field

Medicine (Health Sciences)