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Intrinsic Electrical Activity Drives Small-cell Lung Cancer Progression by Paola Peinado1,11, Marco Stazi1,11, Claudio Ballabio1,11, Michael-Bogdan Margineanu1, is a book available to read on EtoBox.

What is Intrinsic Electrical Activity Drives Small-cell Lung Cancer Progression about?

Nature, doi:10.1038/s41586-024-08575-7Elevated or ectopic expression of neuronal receptors promotes tumour progression in many cancer types1,2; neuroendocrine (NE) transformation of adenocarcinomas has also been associated with increased aggressiveness3. Whether the defning neuronal feature, namely electrical excitability, exists in cancer cells and impacts cancer progression remains mostly unexplored. Small-cell lung cancer (SCLC) is an archetypal example of a highly aggressive NE cancer and comprises two major distinct subpopulations: NE cells and non-NE cells4,5. Here we show that NE cells, but not non-NE cells, are excitable, and their action potential fring directly promotes SCLC malignancy. However, the resultant high ATP demand leads to an unusual dependency on oxidative phosphorylation in NE cells. This fnding contrasts with the properties of most cancer cells reported in the literature, which are non-excitable and rely heavily on aerobic glycolysis. Additionally, we found that non-NE cells metabolically support NE cells, a process akin to the astrocyte–neuron metabolite shuttle6. Finally, we observed drastic changes in the innervation landscape during SCLC progression, whi

Author

Paola Peinado1,11, Marco Stazi1,11, Claudio Ballabio1,11, Michael-Bogdan Margineanu1,

Publisher

x

Published

2025

Language

EN

ISBN

9784158602408