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Ionic strength dependence of F‐actin and glycolytic enzyme associations: A Brownian dynamics simulations approach by Neville Y. Forlemu; Eric N. Njabon; Kristine L. Carlson; Elizabeth S. Schmidt; Victor F. Waingeh; Kathryn A. Thomasson is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Ionic strength dependence of F‐actin and glycolytic enzyme associations: A Brownian dynamics simulations approach about?
## Abstract The association of glycolytic enzymes with F‐actin is proposed to be one mechanism by which these enzymes are compartmentalized, and, as a result, may possibly play important roles for: regulation of the glycolytic pathway, potential substrate channeling, and increasing glycolytic flux. Historically, __in vitro__ experiments have shown that many enzyme/actin interactions are dependent on ionic strength. Herein, Brownian dynamics (BD) examines how ionic strength impacts the energetics of the association of F‐actin with the glycolytic enzymes: lactate dehydrogenase (LDH), glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH), fructose‐1,6‐bisphosphate aldolase (aldolase), and triose phosphate isomerase (TPI). The BD simulations are steered by electrostatics calculated by Poisson‐Boltzmann theory. The BD results confirm experimental observations that the degree of association diminishes as ionic strength increases but also suggest that these interactions are significant, at physiological ionic strengths. Furthermore, BD agrees with experiments that muscle LDH, aldolase, and GAPDH interact significantly with F‐actin whereas TPI does not. BD indicates similarities in binding regi
Who reads Ionic strength dependence of F‐actin and glycolytic enzyme associations: A Brownian dynamics simulations approach?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Neville Y. Forlemu; Eric N. Njabon; Kristine L. Carlson; Elizabeth S. Schmidt; Victor F. Waingeh; Kathryn A. Thomasson
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 0887-3585)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)