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Radiotherapy with concomitant weekly docetaxel for Stages III/IV oropharynx carcinoma. Results of the 98-02 GORTEC Phase II trial by Gilles Calais; Etienne Bardet; Christian Sire; Marc Alfonsi; Jean Bourhis; Béatrix Rhein; Jacques Tortochaux; Yooye Tao Kong Man; Hugues Auvray; Pascal Garaud is a Medicine article available to read on EtoBox.

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Purpose: We designed a prospective Phase II clinical trial to evaluate the addition of weekly chemotherapy using Docetaxel during standard radiation therapy in patients with Stages III and IV oropharynx carcinoma. Methods: A total of 63 patients have been entered in a Phase II multicenter trial. Radiotherapy delivered, with conventional fractionation, 70 Gy in 35 fractions. Patients received during the period of radiotherapy seven cycles of Docetaxel (20 mg/m 2 each week). Results: Radiotherapy compliance was good in respect to total dose, treatment duration, and treatment interruption. The rate of Grade 3 and 4 mucositis was 84%. Grade 3 and 4 skin toxicity occurred in 53% of the patients. Hematologic toxicity was infrequent, with only a 5% rate of Grade 3 or 4 neutropenia. Three-year overall actuarial survival and disease-free survival rates were, respectively, 47% (95% CI ‫؍‬ 39 -68%) and 39% (95% CI ‫؍‬ 30 -57%). The local and regional control rate was 64%. Conclusion: The adjunction of weekly Docetaxel to conventional radiotherapy is feasible. Mucositis and skin toxicity were the major acute toxic effects. Therapeutic results were similar to those observed with concomitant che

Who reads Radiotherapy with concomitant weekly docetaxel for Stages III/IV oropharynx carcinoma. Results of the 98-02 GORTEC Phase II trial?

Author

Gilles Calais; Etienne Bardet; Christian Sire; Marc Alfonsi; Jean Bourhis; Béatrix Rhein; Jacques Tortochaux; Yooye Tao Kong Man; Hugues Auvray; Pascal Garaud

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2004

Language

EN

Field

Medicine (Health Sciences)